Tracking keratin 19-positive cancer stem cells using CYFRA 21-1 in hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Identification of keratin 19‐positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21‐1
The current lack of an easily measurable surrogate marker of cancer stem cells (CSCs) prevents the clinical application of CSCs for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker associated with transforming growth factor beta (TGFβ)/Smad signaling, and that K19+ HCC-CSCs could be a new therapeutic target of TGFβ receptor 1 inhibitor LY215...
متن کاملKeratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma.
PURPOSE Keratin 19 (K19) is a known marker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determined whether K19 can be used as a new CSC marker and therapeutic target in HCC. EXPERIMENTAL DESIGN HCC cell lines were transfected with a K19 promoter-driven enhanced green fluorescence...
متن کاملBiology of Human Tumors Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma
Purpose:Keratin 19 (K19) is a knownmarker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determinedwhether K19 can be used as a new CSC marker and therapeutic target in HCC. Experimental Design: HCC cell lines were transfected with a K19 promoter–driven enhanced green fluorescence pr...
متن کاملCYFRA 21-1 as a tumour marker for bronchogenic carcinoma.
Despite extensive research, the role of the commonly employed tumour markers in the diagnosis of lung carcinoma is yet to be clarified. The utility of a new marker, CYFRA 21-1, in the preoperative evaluation of patients with bronchogenic carcinoma was investigated. CYFRA 21-1 was determined with a radiometric assay in serum of 280 patients with lung cancer and 208 patients with various nonmalig...
متن کاملCyfra 21 - 1 : an Overview
Cytokeratins are group of intermediate filament proteins and based on the tissue expression, cytokeratins are classified into simple epithelial cytokeratin and stratified epithelial cytokeratins. CK expression pattern in the malignant cells are usually retained from the cell of origin, and therefore CK are being used in tumor typing. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid...
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ژورنال
عنوان ژورنال: HPB
سال: 2018
ISSN: 1365-182X
DOI: 10.1016/j.hpb.2018.06.2709